Natural Polyphenols and Apoptosis Induction in Cancer Therapy

Natural polyphenols are secondary metabolites of plants involved in the defense against different types of stress. Due to their potent antioxidant properties, polyphenols have shown potential health benefits in various oxidative stress-associated diseases such as cancer. Polyphenols can induce tumor cell death and interfere with carcinogenesis, tumor growth, and dissemination. Understanding of tumor biology, identification of novel molecular targets, development of specific antitumor agents, and increase the susceptibility of tumor cells to conventional/ targeted treatments are key points for the achievement of effective anticancer therapies.